abstract：:A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and (1)H nuclear magnetic resonance spectra. Cytotoxicity of t...

journal_title：International journal of molecular sciences

authors： Yarim M,Koksal M,Durmaz I,Atalay R

更新日期：2012-01-01 00:00:00

abstract：:Transforming growth factor beta (TGF-β) proteins are multifunctional cytokines whose neural functions are increasingly recognized. The machinery of TGF-β signaling, including the serine kinase type transmembrane receptors, is present in the central nervous system. However, the 3 mammalian TGF-β subtypes have distinct ...

journal_title：International journal of molecular sciences

authors： Dobolyi A,Vincze C,Pál G,Lovas G

更新日期：2012-01-01 00:00:00

abstract：:Activated carbon honeycomb-monoliths with different textural properties were prepared by chemical activation of African palm shells with H(3)PO(4), ZnCl(2) and CaCl(2) aqueous solutions of various concentrations. The adsorbents obtained were characterized by N(2) adsorption at 77 K, and their carbon dioxide adsorption...

journal_title：International journal of molecular sciences

authors： Vargas DP,Giraldo L,Moreno-Piraján JC

更新日期：2012-01-01 00:00:00

abstract：:Inflammation is associated with the development of insulin resistance in Type 2 diabetes mellitus. In the present study, mouse FL83B cells were treated with tumor necrosis factor-alpha (TNF-α) to induce insulin resistance, and then co-incubated with a fraction from wax apple fruit extract (FWFE). This fraction signifi...

journal_title：International journal of molecular sciences

authors： Shen SC,Chang WC,Chang CL

更新日期：2012-01-01 00:00:00

abstract：:Parkinson's disease (PD) is a progressive neurological disorder marked by nigrostriatal dopaminergic degeneration. Evidence suggests that mitochondrial dysfunction may be linked to PD through a variety of different pathways, including free-radical generation and dysfunction of the mitochondrial Complex I activity. In ...

journal_title：International journal of molecular sciences

authors： Lin TK,Cheng CH,Chen SD,Liou CW,Huang CR,Chuang YC

更新日期：2012-01-01 00:00:00

abstract：:The aim of this study was to prepare micronized taxifolin powder using the supercritical antisolvent precipitation process to improve the dissolution rate of taxifolin. Ethanol was used as solvent and carbon dioxide was used as an antisolvent. The effects of process parameters, such as temperature (35-65 °C), pressure...

journal_title：International journal of molecular sciences

authors： Zu S,Yang L,Huang J,Ma C,Wang W,Zhao C,Zu Y

更新日期：2012-01-01 00:00:00

abstract：:A simple and reliable method of ultra-performance liquid chromatography with photodiode array detector (UPLC-PDA) was developed to control the quality of Radix Isatidis (dried root of Isatis indigotica) for chemical fingerprint analysis and quantitative analysis of eight bioactive constituents, including R,S-goitrin, ...

journal_title：International journal of molecular sciences

authors： Shi YH,Xie ZY,Wang R,Huang SJ,Li YM,Wang ZT

更新日期：2012-01-01 00:00:00

abstract：:The mushroom Inonotus obliquus has been widely used as a folk medicine in Russia, Poland and most of the Baltic countries. In this study, water-soluble and alkali-soluble crude polysaccharides (IOW and IOA) were isolated from I. obliquus, and the carbohydrate-rich fractions IOW-1 and IOA-1 were obtained respectively a...

journal_title：International journal of molecular sciences

authors： Mu H,Zhang A,Zhang W,Cui G,Wang S,Duan J

更新日期：2012-01-01 00:00:00

abstract：:Persistent cell shrinkage, called apoptotic volume decrease (AVD), is a pivotal event of apoptosis. Activation of the volume-sensitive outwardly rectifying Cl(-) channel (VSOR) is involved in the AVD induction. On the other hand, activation of the MAP kinase (MAPK) cascade is also known to play a critical role in apop...

journal_title：International journal of molecular sciences

authors： Hasegawa Y,Shimizu T,Takahashi N,Okada Y

更新日期：2012-01-01 00:00:00

abstract：:To decrease the cost of bioethanol production, biomass recalcitrance needs to be overcome so that the conversion of biomass to bioethanol becomes more efficient. CO(2) laser irradiation can disrupt the lignocellulosic physical structure and reduce the average size of fiber. Analyses with Fourier transform infrared spe...

journal_title：International journal of molecular sciences

authors： Tian SQ,Wang ZY,Fan ZL,Zuo LL

更新日期：2012-01-01 00:00:00

abstract：:Levodopa (LD) is used to increase dopamine level for treating Parkinson's disease. The major metabolism of LD to produce dopamine is decarboxylation. In order to understand the metabolism of LD; the electronic structure of levodopa was investigated at the Density Functional DFT/B3LYP level of theory using the 6-311+G*...

journal_title：International journal of molecular sciences

authors： Elroby SA,Makki MS,Sobahi TR,Hilal RH

更新日期：2012-01-01 00:00:00

abstract：:The life of any living organism can be defined as a hurdle due to different kind of stresses. As with all living organisms, plants are exposed to various abiotic stresses, such as drought, salinity, extreme temperatures and chemical toxicity. These primary stresses are often interconnected, and lead to the overproduct...

journal_title：International journal of molecular sciences

authors： Szarka A,Tomasskovics B,Bánhegyi G

更新日期：2012-01-01 00:00:00

abstract：:This paper reports the rapid melt quenching technique preparation for the new family of bismuth-lead germanate glass (BPG) systems in the form of (GeO(2))(60)-(PbO)(40-) (x)-(½Bi(2)O(3))(x) where x = 0 to 40 mol%. Their densities with respect of Bi(2)O(3) concentration were determined using Archimedes' method with ace...

journal_title：International journal of molecular sciences

authors： Sidek HA,Bahari HR,Halimah MK,Yunus WM

更新日期：2012-01-01 00:00:00

abstract：:Apoptosis, also called programmed cell death, is an orderly cellular suicide program that is critical for the development, immune regulation and homeostasis of a multi-cellular organism. Failure to control this process can lead to serious human diseases, including many types of cancer, neurodegenerative diseases, and ...

journal_title：International journal of molecular sciences

authors： Park HH

更新日期：2012-01-01 00:00:00

abstract：:Endothelial cells (ECs) that line the lumen of blood vessels are important players in blood vessel formation, and EC migration is a key component of the angiogenic process. Thus, identification of genes that are specifically or preferentially expressed in vascular ECs and in-depth understanding of their biological fun...

journal_title：International journal of molecular sciences

authors： Wu W,Shi C,Ma F,Balducci J,Huang H,Ji HL,Chang Y,Huang Y

更新日期：2012-01-01 00:00:00

abstract：:The particle sizes of pharmaceutical substances are important for their bioavailability. Bioavailability can be improved by reducing the particle size of the drug. In this study, artemisinin was micronized by the rapid expansion of supercritical solutions (RESS). The particle size of the unprocessed white needle-like ...

journal_title：International journal of molecular sciences

authors： Yu H,Zhao X,Zu Y,Zhang X,Zu B,Zhang X

更新日期：2012-01-01 00:00:00

abstract：:NW-G01, produced by Streptomyces alboflavus 313, is a novel cyclic hexapeptide antibiotic with many potential applications, including antimicrobial activity and antitumor agents. This study developed a system for optimizing medium components in order to enhance NW-G01 production. In this study, Plackett-Burman design ...

journal_title：International journal of molecular sciences

authors： Guo Z,Shen L,Ji Z,Wu W

更新日期：2012-01-01 00:00:00

abstract：:The small abalone, Haliotis diversicolor supertexta, of the family Haliotidae, is one of the most important species of marine shellfish in eastern Asia. Over the past few decades, this species has drastically declined in Korea. Thus, hatchery-bred seeds have been released into natural coastal areas to compensate for t...

journal_title：International journal of molecular sciences

authors： An HS,Lee JW,Hong SW

更新日期：2012-01-01 00:00:00

abstract：:Peanut samples were irradiated (0.0, 5.2, 7.2 or 10.0 kGy), stored for a year (room temperature) and examined every three months. Mycotoxic fungi (MF) were detected in non-irradiated blanched peanuts. A dose of 5.2 kGy was found suitable to prevent MF growth in blanched samples. No MF was detected in in-shell peanuts,...

journal_title：International journal of molecular sciences

authors： de Camargo AC,de Souza Vieira TM,Regitano-d'Arce MA,de Alencar SM,Calori-Domingues MA,Spoto MH,Canniatti-Brazaca SG

更新日期：2012-01-01 00:00:00

abstract：:Changes in the developmental or metabolic state of plastids can trigger profound changes in the transcript profiles of nuclear genes. Many nuclear transcription factors were shown to be controlled by signals generated in the organelles. In addition to the many different compounds for which an involvement in retrograde...

journal_title：International journal of molecular sciences

authors： Krause K,Oetke S,Krupinska K

更新日期：2012-01-01 00:00:00

abstract：:The dried roots of Euphorbia kansui (kansui) have been used for centuries in China as a herbal medicine for edema, ascites, and asthma. The 95% ethanol extract showed a significant inhibition of cell proliferation against human normal cell lines L-O2 and GES-1. Bioassay-guided separation of the 95% ethanol extract fro...

journal_title：International journal of molecular sciences

authors： Zhang L,Gao L,Li Z,Yan X,Yang Y,Tang Y,Cao Y,Ding A

更新日期：2012-01-01 00:00:00

abstract：:The FLOWERING LOCUS T (FT) gene plays crucial roles in regulating the transition from the vegetative to reproductive phase. To understand the molecular mechanism of reproduction, three homologous FT genes were isolated and characterized from Cymbidium sinense "Qi Jian Bai Mo", Cymbidium goeringii and Cymbidium ensifol...

journal_title：International journal of molecular sciences

authors： Huang W,Fang Z,Zeng S,Zhang J,Wu K,Chen Z,Teixeira da Silva JA,Duan J

更新日期：2012-01-01 00:00:00

abstract：:The aim of this work was to compare protective and anti-apoptotic effects of α-tocopherol at nanomolar and micromolar concentrations against 0.2 mM H(2)O(2)-induced toxicity in the PC12 neuronal cell line and to reveal protein kinases that contribute to α-tocopherol protective action. The protection by 100 nM α-tocoph...

journal_title：International journal of molecular sciences

authors： Zakharova IO,Sokolova TV,Bayunova LV,Vlasova YA,Rychkova MP,Avrova NF

更新日期：2012-01-01 00:00:00

abstract：:This paper explores the effect of granulocyte colony-stimulating factor (G-CSF) on mouse myocardial microvascular endothelial cell (CMECs) proliferation. CMECs were harvested from C57/BL6 mice. CMECs were cultured in medium containing G-CSF (0 ng/mL, 20 ng/mL, 40 ng/mL, 60 ng/mL) for five days. Proliferative activity ...

journal_title：International journal of molecular sciences

authors： Li J,Zou Y,Ge J,Zhang D,Guan A,Wu J,Li L

更新日期：2011-02-22 00:00:00

abstract：:The specific rates of solvolysis of neopentyl chloroformate (1) have been determined in 21 pure and binary solvents at 45.0 °C. In most solvents the values are essentially identical to those for ethyl and n-propyl chloroformates. However, in aqueous-1,1,1,3,3,3-hexafluoro-2-propanol mixtures (HFIP) rich in fluoroalcoh...

journal_title：International journal of molecular sciences

authors： D'Souza MJ,Carter SE,Kevill DN

更新日期：2011-02-15 00:00:00

abstract：:The present study was undertaken to develop a rat model for monitoring the early development of breast cancer. Twelve female rats were divided into two groups of six rats that were either treated with N-methyl-N-nitrosourea to induce breast cancer or with bacterial lipopolysaccharide to induce inflammation. Serum samp...

journal_title：International journal of molecular sciences

authors： Golbabapour S,Pang WW,George J,Pasupati T,Abdul-Rahman PS,Hashim OH

更新日期：2011-02-07 00:00:00

abstract：:Mycobacterium immunogenum, a newly identified member of the Mycobacterium chelonae_M. abscessus complex is considered a potential etiological agent for hypersensitivity pneumonitis (HP) in machine workers exposed to contaminated metalworking fluid (MWF). This study investigated the biocidal efficacy of the frequently ...

journal_title：International journal of molecular sciences

authors： Selvaraju SB,Khan IU,Yadav JS

更新日期：2011-01-20 00:00:00

abstract：:Future therapeutic intervention that could effectively decelerate the rate of degeneration within the substantia nigra pars compacta (SNc) could add years of mobility and reduce morbidity associated with Parkinson's disease (PD). Neurodegenerative decline associated with PD is distinguished by extensive damage to SNc ...

journal_title：International journal of molecular sciences

authors： Mazzio EA,Close F,Soliman KF

更新日期：2011-01-17 00:00:00

abstract：:Laser induced opening of the C(60) cage is studied by a semiclassical electron-radiation-ion dynamics technique. The simulation results indicate that the C(60) cage is abruptly opened immediately after laser excitation. The opening of the C(60) cage induces a quick increase in kinetic energy and a sharp decrease in el...

journal_title：International journal of molecular sciences

authors： Tang H,Li H,Dou Y

更新日期：2011-01-13 00:00:00

abstract：:Past research has demonstrated that oestrogenic compounds produce strand breaks in the DNA of sperm and lymphocytes via reactive oxygen species (ROS). In the current investigation, sperm and lymphocytes were treated in vitro with oestrogenic compounds (diethylstilboestrol, progesterone, 17β-oestradiol, noradrenaline a...

journal_title：International journal of molecular sciences

authors： Cemeli E,Anderson D

更新日期：2011-01-01 00:00:00

abstract：:D-(+)-Galactose-conjugated single-walled carbon nanotubes (SWCNTs) were synthesized for use as biosensors to detect the cancer marker galectin-3. To investigate the binding of galectin-3 to the d-(+)-galactose-conjugated SWCNTs, an electrochemical biosensor was fabricated by using molybdenum electrodes. The binding af...

journal_title：International journal of molecular sciences

authors： Park YK,Bold B,Lee WK,Jeon MH,An KH,Jeong SY,Shim YK

更新日期：2011-01-01 00:00:00

abstract：:Aminoethylcysteine ketimine decarboxylated dimer is a natural sulfur-containing compound detected in human plasma and urine, in mammalian brain and in many common edible vegetables. Over the past decade many studies have been undertaken to identify its metabolic role. Attention has been focused on its antioxidant prop...

journal_title：International journal of molecular sciences

authors： Macone A,Fontana M,Barba M,Botta B,Nardini M,Ghirga F,Calcaterra A,Pecci L,Matarese RM

更新日期：2011-01-01 00:00:00

abstract：:Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human diseases such as tumor, Parkinson disease, Alzheimer disease, diabetes, and so on. These disease-ass...

journal_title：International journal of molecular sciences

authors： Wang J,Cao Z,Zhao L,Li S

更新日期：2011-01-01 00:00:00

abstract：:The endo-β-1,4-glucanase gene celE from the anaerobic fungus Orpinomyces PC-2 was placed under the control of an alcohol oxidase promoter (AOX1) in the plasmid pPIC9K, and integrated into the genome of a methylotrophic yeast P. pastoris GS115 by electroporation. The strain with highest endo-β-1,4-glucanase activity wa...

journal_title：International journal of molecular sciences

authors： Jin X,Meng N,Xia LM

更新日期：2011-01-01 00:00:00

abstract：:Cell proliferation is an important biological process during myogenesis. Tob1 encoded a member of the Tob/BTG family of anti-proliferative proteins. Our previous LongSAGE (Long Serial Analysis of Gene Expression) analysis suggested that Tob1 was differentially expressed during prenatal skeletal muscle development. In ...

journal_title：International journal of molecular sciences

authors： Yuan J,Cao JY,Tang ZL,Wang N,Li K

更新日期：2011-01-01 00:00:00

abstract：:Both genetic and epigenetic alterations can control the progression of cancer. Genetic alterations are impossible to reverse, while epigenetic alterations are reversible. This advantage suggests that epigenetic modifications should be preferred in therapy applications. DNA methyltransferases and histone deacetylases h...

journal_title：International journal of molecular sciences

authors： Cai FF,Kohler C,Zhang B,Wang MH,Chen WJ,Zhong XY

更新日期：2011-01-01 00:00:00

abstract：:Green fluorescent protein (GFP) has been widely used in several molecular and cellular biology applications, since it is remarkably stable in vitro and in vivo. Interestingly, native GFP is resistant to the most common chemical denaturants; however, a low fluorescence signal has been observed after acid-induced denatu...

journal_title：International journal of molecular sciences

authors： Mares RE,Meléndez-López SG,Ramos MA

更新日期：2011-01-01 00:00:00

abstract：:The Eisenberg plot or hydrophobic moment plot methodology is one of the most frequently used methods of bioinformatics. Bioinformatics is more and more recognized as a helpful tool in Life Sciences in general, and recent developments in approaches recognizing lipid binding regions in proteins are promising in this res...

journal_title：International journal of molecular sciences

authors： Keller RC

更新日期：2011-01-01 00:00:00

abstract：:Hibiscus aridicola (Malvaceae) is an endangered ornamental shrub endemic to the dry-hot valleys of Jinsha River in southwest China. Only four natural populations of H. aridicola exist in the wild according to our field investigation. It can be inferred that H. aridicola is facing a very high risk of extinction in the ...

journal_title：International journal of molecular sciences

authors： Zhang L,Sun W,Wang Z,Guan K,Yang J

更新日期：2011-01-01 00:00:00

abstract：:We revisit the classical problem of nucleated polymerisation and derive a range of exact results describing polymerisation in systems intermediate between the well-known limiting cases of a reaction starting from purely soluble material and for a reaction where no new growth nuclei are formed. ...

journal_title：International journal of molecular sciences

authors： Cohen SI,Vendruscolo M,Dobson CM,Knowles TP

更新日期：2011-01-01 00:00:00